Fondata a Firenze nel 2015, Valenti&Partners (V&P) offre servizi avanzati in ricerca, sviluppo e progettazione razionale di prodotti innovativi in tutti i campi dove la chimica è coinvolta, in particolar modo nelle scienze farmaceutiche, nella alimentazione umana ed animale, nella cosmesi dermofunzionale.
I nostri servizi di innovazione, fondi di investimento che hanno nella loro strategia il finanziamento di stadi iniziali d’impresa (early stage), sono rivolti ad imprenditori privati o istituzionali che vogliono immettere sul mercato un prodotto innovativo o intraprendere un’attività imprenditoriale innovativa, piccole e medie società che vogliono penetrare il mercato con prodotti innovativi esclusivi.
Valenti&Partners Team
Salvatore Valenti
Annalisa Santucci
Marco Paolino
Stefania Lamponi
Vincenzo Calderone
Salvatore Valenti
Salvatore Valenti, PhD
Drug Discovery, Medicinal Chemistry, Innovation Director
Selected Patents and Pubblications:
- DEVELOPMENT OF NOVEL CYCLIC PEPTIDES AS PRO-APOPTOTIC AGENTS ARTICLE IN EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 117 · APRIL 2016
- DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF IMIDAZO[1,5- A ]QUINOLINE AS HIGHLY POTENT LIGANDS OF CENTRAL BENZODIAZEPINE RECEPTORS ARTICLE IN JOURNAL OF MEDICINAL CHEMISTRY 59(7) · MARCH 2016
- RADIOSYNTHESIS AND PRELIMINARY BIOLOGICAL EVALUATION OF [18F]VC701, A RADIOLIGAND FOR TRANSLOCATOR PROTEIN ARTICLE IN MOLECULAR IMAGING 14(4):7-17 · MAY 2015
- NOVEL ANALGESIC/ANTI-INFLAMMATORY AGENTS: 1 , 5 – DIARYLPYRROLE NITROOXYALKYL ETHERS AND RELATED COMPOUNDS AS CYCLOOXYGENASE-2 INHIBITING NITRIC OXIDE DONORS.
- ARTICLE IN J MED CHEM. 2013 APR 25;56(8):3191-206
- CORRECTION TO NOVEL ANALGESIC/ANTI-INFLAMMATORY AGENTS: 1,5-DIARYLPYRROLE NITROOXYALKYL ETHERS AND RELATED COMPOUNDS AS CYCLOOXYGENASE-2 INHIBITING NITRIC OXIDE DONORS
- ARTICLE IN JOURNAL OF MEDICINAL CHEMISTRY 56(11) · JUNE 2013
Annalisa Santucci
Annalisa Santucci, PhD
Circular Economy
Full Professor
Selected of 288 publications:
- Braconi, D., Millucci, L., Parisi, M.L., Spiga, O., & Santucci, A. (2021). Omics-based technologies for food authentication and traceability. In Food Authentication and Traceability (pp. 215-245). Charis M. Galanakis.
- Braconi, D., Cicaloni, V., Spiga, O., & Santucci, A. (2021). Personalized nutrition and omics technologies. In Food Technology Disruptions (pp. 37-71). Charis M. Galanakis.
- Spiga, O., Cicaloni, V., Dimitri, G.M., Pettini, F., Braconi, D., Bernini, A., et al. (2021). Machine learning application for patient stratification and phenotype/ genotype investigation in a rare disease. BRIEFINGS IN BIOINFORMATICS.
- Spiga, O., Cicaloni, V., Visibelli, A., Davoli, A., Paparo, M.A., Orlandini, M., et al. (2021). Towards a precision medicine approach based on machine learning for tailoring medical treatment in alkaptonuria. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3), 1-10.
- Braconi, D., & Santucci, A. (2021). Omics Perspectives in Food Science. In Comprehensive Foodomics (pp. 558-567). Alejandro Cifuentes.
Marco Paolino
Marco Paolino, PhD
Polymer and Material Science
Selected Publications:
- Paolino, M., Giovannini, T., Manathunga, M., Latterini, L., Zampini, G., Pierron, R., et al. (2021). On the Transition from a Biomimetic Molecular Switch to a Rotary Molecular Motor. THE JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 12(16), 3875-3884. –
- Atrei, A.M., Innocenti, C., Lamponi, S., Paesano, S., Leone, G., Reale, A., et al. (2020). Covalent hyaluronic-based coating of magnetite nanoparticles: Preparation, physicochemical and biological characterization. MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS, 107, 1-14 [10.1016/j.msec.2019.110271].
- Mugnaini, C., Brizzi, A., Vinciarelli, G., Paolino, M., & Corelli, F. (2020). New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands. NEW JOURNAL OF CHEMISTRY, 44, 16218-16226. –
- Gueye, M., Paolino, M., Gindensperger, E., Haacke, S., Olivucci, M., & Leonard, J. (2020). Vibrational coherence and quantum yield of retinal-chromophore-inspired molecular switches†. FARADAY DISCUSSIONS, 221(0), 299-321.
- Paolino, M., Reale, A., Razzano, V., Giorgi, G., Giuliani, G., Villafiorita-Monteleone, F., et al. (2020). Design, synthesis, structure, and photophysical features of highly emissive cinnamic derivatives. NEW JOURNAL OF CHEMISTRY, 44(32), 13644-13653.
Stefania Lamponi
Stefania Lamponi, PhD
Biological Evaluation
- Potential use of plants and their extracts in the treatment of coagulation disorders in COVID-19 disease: a narrative review 2021 Stefania Lamponi
- Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 2021 Relitti N.; Saraswati A.P.; Chemi G.; Brindisi M.; Brogi S.; Herp D.; Schmidtkunz K.; Saccoccia F.; Ruberti G.; Ulivieri C.; Vanni F.; Sarno F.; Altucci L.; Lamponi S.; Jung, M.; Gemma S.; Butini S.; Campiani G.
- Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity. 2021
Relitti N.; Federico S.; Pozzetti L.; Butini S.; Lamponi S.; Taramelli D.; D’Alessandro S.; Martin R.E.; Shafik S. H.; Summers R. L.; Babij S. K.; Habluetzel A.; Tapanelli S.; Caldelari R.; Gemma S.; Campiani G. - Phosphorylated xanthan gum-Ag(I) complex as antibacterial viscosity enhancer for eye drops formulation. 2021
Leone, G.; Pepi, S.; Consumi, M.; Mahdizadeh, F. F.; Lamponi, S.; Magnani, A. - Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. 2021 Campiani Giuseppe; Cavella Caterina; Osko Jeremy D; Brindisi Margherita; Relitti Nicola; Brogi Simone; Saraswati A. Prasanth; Federico Stefano; Chemi Giulia; Maramai Samuele; Carullo Gabriele; Jaeger Benedikt; Carleo Alfonso; Benedetti Rosaria; Sarno Federica; Lamponi Stefania; et al.
Vincenzo Calderone
Vincenzo Calderone
Full Professor
Science and Pharmacology of Medicinal Plants
Seletcted Pubblications:
- Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications
Pellegrini C, Antonioli L, Calderone V, Colucci R, Fornai M, Blandizzi C.
Prog Neurobiol. 2020 Aug - The “irisin system”: From biological roles to pharmacological and nutraceutical perspectives.
Flori L, Testai L, Calderone V.
Life Sci. 2021 Feb 15;267 - NLRP3 inflammasome in cardiovascular diseases: Pathophysiological and pharmacological implications.
Pellegrini C, Martelli A, Antonioli L, Fornai M, Blandizzi C, Calderone V.
Med Res Rev. 2021 Jul;41(4):1890-1926 - Organic Isothiocyanates as Hydrogen Sulfide Donors.
Martelli A, Citi V, Testai L, Brogi S, Calderone V.
Antioxid Redox Signal. 2020 Jan 10;32(2):110-144. - Cinnamides Target Leishmania amazonensis Arginase Selectively.